The vast array of research indicates that the polyphenols contained in OProCyn may support oral health through a number of mechanisms, such as:
- The analysis of the literature supports the anti-bacterial role of grape seed polyphenols on cariogenic (dental cavity-producing) bacteria suggesting (1) a direct effect against these specific (S.mutans) bacteria; (2) an interaction with microbial membrane proteins inhibiting the adherence of bacterial cells to the tooth surface; and (3) the inhibition of enzymes which breakdown sugar and starch (glucosyl transferase and amylase, all of which can promote tooth decay.
- Grape seed extract reduces biofilms (complex, impenetrable bacterial colonies) on teeth which can lead to gingivitis (gum inflammation) and tooth decay.
- Grape seed extract aids in the preservation of the stability of dentin collagen (inner tooth material) and accelerating the conversion of soluble collagen to insoluble collagen, helping to prevent tooth decay.
- Grape seed extract promotes the remineralization of dentin collagen, which is the scaffold for mineral deposition in teeth required for health tooth structure (inclusive of enamel).
- Grape seed extract supports the structure of the tooth after bleaching and prior to bonding procedures, effectively neutralizing the deleterious effects of bleaching and increasing the bond strength significantly.
- Remineralization is an effective treatment that may stop or reverse early tooth decay. Grape seed extract is a natural cross-linking agent for stabilizing collagen matrices in dentine as well as and soft tissue.
- Grape seed extract may also play a role in decreasing collagen digestibility by its inhibitory effect on proteases such as intrinsic metalloproteinases, thus decreasing degradation rates of both the sound and caries-affected dentine.
- Grape seed extract may have a differentially anti-proliferative function against oral cancer cells via differential apoptosis, oxidative stress and DNA damage.
Macedo GV, Yamauchi M, Bedran-Russo AK. Effects of chemical cross-linkers on caries-affected dentine bonding. J Dent Res. 2009;88:1096–1100. [PMC free article] [PubMed]
Caries Res. 2011 Nov; 45(5): 443–447.
Tang CF1, Fang M, Liu RR, Dou Q, Chai ZG, Xiao YH, Chen JH.
The role of grape seed extract in the remineralization of demineralized dentine: micromorphological and physical analyses.Arch Oral Biol. 2013 Dec;58(12):1769-76. doi: 10.1016/j.archoralbio.2013.09.007. Epub 2013 Oct 4.PMID:24200303
Xie Q1, Bedran-Russo AK, Wu CD.
In vitro remineralization effects of grape seed extract on artificial root caries.J Dent. 2008 Nov;36(11):900-6. doi: 10.1016/j.jdent.2008.07.011. Epub 2008 Sep 25.PMID:18819742
- Pavan,a Q. Xie,b A.T. Hara,c and A.K. Bedran-Russoa,* Biomimetic Approach for Root Caries Prevention Using a Proanthocyanidin-Rich Agent.Caries Res. 2011 Nov; 45(5): 443–447.
Houde V, Grenier D, Chandad F. Protective effects of grape seed proanthocyanidins against oxidative stress induced by lipopolysaccharides of periodontopathogens. J Periodontol. 2006 August 77(8):1371-9.
BMC Complement Altern Med. 2015 Mar 29;15:94. doi: 10.1186/s12906-015-0621-8.
Concentration effects of grape seed extracts in anti-oral cancer cells involving differential apoptosis, oxidative stress, and DNA damage. Yen CY1,2, Hou MF3,4,5, Yang ZW6, Tang JY7,8,9, Li KT10, Huang HW11, Huang YH12, Lee SY13, Fu TF14, Hsieh CY15, Chen BH16, Chang HW17,18,19,20.