Oxidative Stress: A Reality Check on the
Impacts of Your Environment
What is Oxidative Stress? It is defined as a condition of increased oxidant production in cells, characterized by the release of free radicals and resulting in cellular degeneration. Free radicals are unstable molecules that damage or “oxidize” cells throughout the body in a process called oxidative stress.
What contributes to oxidative stress? The answer begins with eating too many calories, sugars and refined carbohydrates and continues with exposure to tobacco smoke, alcohol, air pollutants, lack of sleep and of course, stress. But there are things you can do about it!
Oxidative Stress – Inflammation
Aging decreases the positive regulators of Nrf2 and increases the negative regulators of Nrf2, thus leaving the body more susceptible to chronic inflammation, atherosclerosis, toxic exposure and oxidative stress. The Nrf2/ARE signaling pathway can be directly and positively activated by a number of the polyphenols found in OProCyn.
Because of the exceptional sourcing and quality practices upheld by Advanced Functional Nutrition, OProCyn is designed with this support in mind.
Endogenous biological substances are those originating or produced naturally within your body’s tissues or cells. The activation of the body’s endogenous antioxidant defences and Phase 2 enzyme systems is through activation of the broadly researched and highly conserved evolutionary defence pathway called the Nuclear Erythroid 2 Related Factor 2 (Nrf2) pathway.
Nrf2 regulates the expression of a large battery of genes involved in the cellular antioxidant and anti-inflammatory pathways as well as in mitochondrial protection
Nrf2 therefore acts as a master regulator of the cellular antioxidant response of over 250 phase 2 genes (and greater than 90% of the anti-oxidant genes) that should be referred to as “pro-life genes” since they save cells from cell death.
Nrf2 activation can at once regulate multiple phyto-protective enzymes that are capable of simultaneous inhibition of major pathogenic pathways, such as oxidative stress, lipid peroxidation, endothelial dysfunction, neuroinflammation and mitochondrial dysfunction.
These expressed phyto-protective enzymes (due to Nrf2 activated by select polyphenols) are cytoprotective proteins are referred to as the “ultimate antioxidants,” as they are not consumed during their antioxidant actions, can catalyze a wide variety of detoxification reactions and have relatively long half-lives.
These same expressed phyto-protective enzymes detoxify many harmful substances that can be excreted readily from the body.
Loss of or reduced Nrf2 signaling increases susceptibility to acute toxicity, inflammation, carcinogenesis, and many chronic diseases.
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