Numerous studies have highlighted the key role of oxidative stress and inflammation in age-related diseases such as arthritis, obesity, type 2 diabetes, age-related macular degeneration (AMD) and Alzheimer’s disease (AD). In aging cells the natural antioxidant capacity declines compared to younger cells and the overall efficiency of repair systems against cellular damage becomes impaired. Research gives us convincing data that supplementation with polyphenols containing resveratrol, proanthocyanidins, anthocyanins and catechins as found in OProCyn can increase cellular antioxidant defenses and promote overall health of the individual.
Polyphenols in OProCyn are shown to activate the Nrf2 defense pathway, which acts as a “master regulator” of the cellular antioxidant response of over 250 phase 2 genes referred to as pro-life genes.
Because of the exceptional sourcing and quality practices upheld by Advanced Functional Nutrition, OProCyn is designed with this support in mind.
Endogenous biological substances are those originating or produced naturally within your body’s tissues or cells. The activation of the body’s endogenous antioxidant defences and Phase 2 enzyme systems is through activation of the broadly researched and highly conserved evolutionary defence pathway called the Nuclear Erythroid 2 Related Factor 2 (Nrf2) pathway.
Nrf2 regulates the expression of a large battery of genes involved in the cellular antioxidant and anti-inflammatory pathways as well as in mitochondrial protection
Nrf2 therefore acts as a master regulator of the cellular antioxidant response of over 250 phase 2 genes (and greater than 90% of the anti-oxidant genes) that should be referred to as “pro-life genes” since they save cells from cell death.
Nrf2 activation can at once regulate multiple phyto-protective enzymes that are capable of simultaneous inhibition of major pathogenic pathways, such as oxidative stress, lipid peroxidation, endothelial dysfunction, neuroinflammation and mitochondrial dysfunction.
These expressed phyto-protective enzymes (due to Nrf2 activated by select polyphenols) are cytoprotective proteins are referred to as the “ultimate antioxidants,” as they are not consumed during their antioxidant actions, can catalyze a wide variety of detoxification reactions and have relatively long half-lives.
These same expressed phyto-protective enzymes detoxify many harmful substances that can be excreted readily from the body.
Loss of or reduced Nrf2 signaling increases susceptibility to acute toxicity, inflammation, carcinogenesis, and many chronic diseases.
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